CASE STUDIES
Therapies with PATHELEN® HYBRID

In recent years, PATHELEN® HYBRID therapy has been tested on patients in various hospitals and continuously developed. Various wound infections were successfully treated until the patient had completely healed and recovered.

Name:

B.G.O., female, 67 y.o.

Diagnosis:

Infected wound of abdominal wall

Microflora:

Staphylococcus aureus

White blood cells (WBCs): 10,2×109/l

Banded neutrophils – 8%.

 

The patient was acepted with complaints on the pain and wounds on the anterior abdominal wall, the temperature of 36,7 C.Ps – 98/min. AP – 130/80 mm Hg.

The disease has started 4 days ago.

Name:

N.O.O., male, 62 y.o.

Diagnosis:

Type 2 diabetes mellitus, diabetic foot syndrome neuroischemic form, abscess of the left tibia, abscess of the left leg.

Microflora:

Staphylococcus aureus

White blood cells (WBCs): 13,5×109/l

Banded neutrophils – 28%.

 

The patient was accepted with complaints on pain and wounds on the anterior abdominal wall, the temperature 38.2C.Ps – 100/min. AP – 120/80 mm Hg.

The disease has began 6 days ago.

Name:

M.I., female, 20 y.o.

Diagnosis:

Acute posterior anorectal abscess

Case relevant history:

Neurocirculatory dystonia, mixed type.
Epilepsy

Microflora:

Escherichia coli

White blood cells (WBCs): 10,0×109/l

Banded neutrophils – 8%.

The patient was admitted with complaints of pain in his left leg, redness and itching on the internal surface of the left tibia and femur.

Fever up to 39.5 °C, hemoglobin: Hb-80 g/l, and frequency of puls – 110/min showed that the patient had Systemic Inflammatory Response Syndrome (SIRS). Based on existence of purulent inflammation and SIRS, the Patient was diagnosed – Sepsis.

Name:

E.A.M., female, 43 y.o.

Diagnosis:

Carbuncle anterior abdominal wall

Microflora:

Staphylococcus saprophyticus

Staphylococcus aureus

White blood cells (WBCs): 13,3×109/l

Banded neutrophils – 7%.

Complaints on the pain and swelling near the anus. Fever up to 37.9 °C. Heart rate – 88 bpm. AP – 120/70 mm Hg. The disease began 2 days ago.

Name:

L.V.I., male, 38 y.o.

Diagnosis:

Acute ischiorectal abscess. Sepsis

Case relevant history:

Myocardiosclerosis. Atrial flutter-fibrillation. Tachysystole. Heart failure I-II A.

Alimentary-constitutional obesity (weight- 170 kg; body mass index- 46)

Microflora:

Escherichia coli

Enterococcus faecalis

White blood cells (WBCs): 21,6×109/l

Banded neutrophils – 10%.

 

Fever up to 39.5 °C, and heart rate – 98 bpm showed that the patient had Systemic Inflammatory Response Syndrome (SIRS). Based on existence of purulent inflammation and SIRS, the Patient was diagnosed – Sepsis

Name:

M.A., female, 78 y.o.

Diagnosis:

Necrotizing fasciitis of the left shin Thrombophlebitis of the left tibia. Chronic venous insufficiency 6c.

Microflora:

Staphylococcus aureus

Pseudomonas aeruginosa

White blood cells (WBCs): 14,03×109/l

Banded neutrophils – 19%.

The patient was hospitalized with complaints of pain in the left leg, the temperature of 37.8C.

Ps – 100/min. AP – 140/80 mm Hg.

Name:

Z.V. male, 68 y.o.

Diagnosis:

Type 2 diabetes mellitus, diabetic foot syndrome neuroischemic form; wound infection of the left foot after amputation of fingers

Case relevant history:

Ischemic heart disease

Hypertensive heart disease

Heart failure

Atrial fibrillation is a permanent form

Microflora:

Staphylococcus aureus

Staphylococcus epidermidis

Enterococcus faecium

White blood cells (WBCs): 8,0×109/l

Banded neutrophils – 8%

 

On the lateral surface of the left foot was observed infected wound sized 9 х 3 cm

Name:

C.M., male, 44 y.o.

Diagnosis:

Acute anterior anorectal extrasphincteric abscess

Case relevant history:

Ischemic heart diseas

Atherosclerotic cardiosclerosis.

Heart failure I

Supraventricular extrasystoles

Microflora:

Escherichia coli

Acinetobacter baumannii

Enterococcus faecium

White blood cells (WBCs): 6,4×109/l

Banded neutrophils – 9%.

Skin hyperemia without precise borders is visualized in 13 hours on conditional dial in the perianal region, in 4-5 cm from the anus – infiltrate 6×11 cm, the infiltrate is hot to the touch, painful, with soft area in its center.

Name:

M.T., male, 20 y.o.

Diagnosis:

Acute pilonidal abscess (sacrococcygeal region).

Microflora:

Escherichia coli (E. coli)

White blood cells (WBCs): 12,5×109/l

Banded neutrophils – 11%.

Complaints on the pain and swelling in the cleft on the top of buttocks.

Name:

l.M., female, 68 y.o.

Diagnosis:

Necrotic abscess suprapubic area and perineum

Case relevant history:

Type 2 diabetes mellitus

Chronic iron deficiency anemia

Microflora:

Proteus mirabilis

Staphylococcus epidermidis

Klebsiella orytoca

Citrobacter freundii

Klebsiella pneumoniae

Staphylococcus epidermidis

White blood cells (WBCs): 18,2×109/l

Banded neutrophils – 29%.

 

Fever up to 38.5 °C, leukocytosis – 18,2×109/l with banded neutrophils – 29%, hemoglobin: Hb-72g/l, and frequency of pulse – 120/min showed that the patient had Systemic Inflammatory Response Syndrome (SIRS). Based on existence of purulent inflammation and SIRS, the Patient was diagnosed – Sepsis

Name:

B.A., male, 61 y.o.

Diagnosis:

Diabetes mellitus type 2. Diabetic foot syndrome neuroischemic form, foot abscess, osteomyelitis of the foot bones. Sepsis

Case relevant history:

Chronic iron deficiency anemia caused by foot phlegmon

Microflora:

Enterococcus faecalis (E. faecalis)

Staphylococcus saprophyticus (S. Saprophyticuі)

Staphylococcus epidermidis (S. epidermidis)

White blood cells (WBCs): 20,3×109/l

Banded neutrophils – 17%.

 

Complaints on the pain in the foot, pus from the wound, increasing fever up to 39.5 °C

Name:

A.N., male, 59 y.o.

Diagnosis:

Chronic infected wound to the left lower leg

Case relevant history:

Diabetes mellitus type 2. Chronic venous disorders.

Microflora:

Staphylococcus saprophyticus (S. Saprophyticuі)

Staphylococcus epidermidis (S. epidermidis)

White blood cells (WBCs): 8,0×109/l

Banded neutrophils – 6%.

 

Complaints on the wound on the front surface of the lower part of the left leg which patient has had for the last 5 months. The patient noted constant pain in the wound.

Name:

  1. V., male, 48 y.o.

Diagnosis:

Diabetes mellitus type 2, diabetic foot syndrome neuropathic form, and trophic ulcers of both feet. Wagner 2 right foot. Wagner 3 left foot.

Microflora:

Staphylococcus aureus (S. aureus) MRSA

Enterobacter cloacae (E. cloacae)

Staphylococcus epidermidis (S. epidermidis)

White blood cells (WBCs): 4,8×109/l

Banded neutrophils – 5%.

 

The patient was accepted into the hospital with complaints on the wound on the left foot, the patient have noted the wound 6 months ago.

Name:

I.V., male, 50 y.o.

Diagnosis:

Acute posterior ischio- and retrorectal extrasphincteric abscess. Sepsis

Case relevant history:

Diabetes mellitus type 2. Obesity. Hypertensive heart disease, stage ІІ. Ischemic heart disease.

Microflora:

Acinetobacter baumannii (A. baumannii)

Escherichia coli (E. coli)

White blood cells (WBCs): 12.0×109/l

Banded neutrophils – 9%.

 

Fever up to 39.5 °C, leukocytosis – 12.0×109/l, heart rate 120 bpm and breathing frequency 20/min showed that the patient had Systemic Inflammatory Response Syndrome. Based on existence of purulent inflammation and SIRS, the Patient was diagnosed – Sepsis.

 

Name:

L.B., female, 63 y.o.

Diagnosis:

Acute right sided ischiorectal abscess

Case relevant history:

Diabetes mellitus type 2, Obesity (body mass index – 37 kg/m2), Arterial hypertension, Ischemic heart disease, Atherosclerotic cardiosclerosis, Metabolic cardiomyopathy

Microflora: 

Enterococcus faecalis

Staphylococcus epidermidis

White blood cells (WBCs): 18.2×109/l

Banded neutrophils – 19%.

 

Fever up to 38.5 °C, leukocytosis – 18.2×109/l with banded neutrophils – 19%, heart rate – 110 bpm showed that the patient had Systemic Inflammatory Response Syndrome. Based on existence of purulent inflammation and SIRS, the Patient was diagnosed – Sepsis.

Name:

L.S., female, 40 y.o.

Diagnosis:

Acute posterior retro-rectal trans-sphincteric abscess

Case relevant history:

Arterial hypertension

Microflora:

Escherichia coli (E. coli)

Enterococcus faecium (E. faecium)

White blood cells (WBCs): 9.0×109/l

Banded neutrophils – 12%.

 

Fever up to 38.2 °C, leukocytosis – 9.0×109/l with banded neutrophils – 12% showed that the patient had Systemic Inflammatory Response Syndrome.